Oxidative stress (OxS) is a disturbance associated with the pathogenesis of diabetes/pre-diabetes, obesity, cancer, ageing, inflammation, apoptosis, neurodegenerative disorders and cardiovascular diseases. Metabolic syndrome (MetS), also called insulin-resistance syndrome, is a complex of disorders, each of which contributes to cardiovascular risk, associated with imbalance between production and inactivation of reactive oxygen species. In the last years the potential role of OxS in MetS is rapidly evolving.
Methods: The present study was designed to investigate the effect of Piracetam, Resveratrol and propylene glycol extract of Royal jelly on behavioral functions and OxS markers in serum of fructose-drinking rats.
Results: MetS induced by 60% fructose solution in rats leads to impairment of cognitive functions, based on the development of OxS. Royal jelly extract and Resveratrol show pronounced antiamnesic activity in rats with MetS. All studied drugs inhibit reactions of free radical oxidation in varying degree.
Conclusions: This study indicates an important role of OxS in the development of cognitive disorders that appear in consequence of MetS. In experimental model of MetS the largest antiamnesic and antiradical efficacy was observed for propylene glycol extract of Royal jelly.