Vol. 4, Issue 8 (2015)

Author(s):
KM Yatsyuk, MI Fedorovska, OM Barna

Abstract:
This work is aimed to develop granules composition and technology based on condensed cranberry juice for urological use; study their technological properties according to the requirements of the Ukraine State Pharmacopoeia. At the first stage it was composed the composition of excipients (diluents and disintegrants) to obtain granules with maximum quantity of condensed cranberry juice by wet granulation method. The greatest amount of active substance was incorporated by mixtures: glucose – guar gum (10:4), sucrose– guar gum (10:4), and lactose– guar gum (10:4) in the amount of 9, 5 and 9 parts of condensed cranberry juice respectively. The next step was to determine particle size distribution, disintegration and mechanical strength of above samples – all granules were submitted these criteria according with the Ukraine State Pharmacopoeia requirements.