Vol. 4, Issue 6 (2015)
Antidiabetic and Antihyperlipidemic Effects of Rhizophora apiculata Blume Extracts
Gurudeeban S, Satyavani K, Sengottuvel S, Thamotharan G, Ramanathan T
Objective: The present study aimed to evaluate the antidiabetic and antihyperlipidemic activities of ethanolic leaves extracts of Rhizophora apiculata and its dichloromethane and aqueous basic fraction in experimental diabetic rats.
Methods: The leaf materials of R. apiculata extracted with 80% ethanol and determined their phytochemicals constituents. Insulin-dependent diabetes mellitus (IDDM) was induced by single intraperitoneal injection of streptozotocin (60 mg/kg body weight), and Non-IDDM was induced by single intraperitoneal injection of streptozotocin (60 mg/kg body weight), after 15 min 120 mg/kg of nicotinamide injected intraperitoneally. The rats administrated with oral doses of 250 mg/kg body weight of the ethanolic extract, dichloromethane (DCM-F) and aqueous basic fraction (AB-F) of R. apiculata up to 21 days respectively. The blood glucose level estimated on 0th, 7th, 14th, and 21st day by one touch glucometer. On the 21st day, the level of serum cholesterol, triglycerides and high-density lipoprotein cholesterol (HDL-C) were evaluated.
Results: The phytochemical studies specified the alkaloids, flavonoids, and terpenoids present in the extracts. The rats treated with dichloromethane fraction indicated significant reduction in blood glucose (P < 0.01), serum cholesterol (P < 0.05) and triglycerides (P < 0.05) levels whereas HDL-C level was found to be increased (P < 0.05) as compared with the diabetic control group in both types. Conclusion: Dichloromethane fraction of R. apiculata has prominent antidiabetic effect in IDDM and NIDDM experimental models. Further studies will confirm the active constituent in this fraction.
How to cite this article:
Gurudeeban S, Satyavani K, Sengottuvel S, Thamotharan G, Ramanathan T. . The Pharma Innovation Journal. 2015; 4(6): 31-35.