Vol. 4, Issue 5 (2015)

Author(s):
Tanvir Ahmad Chowdhury, A.T.M.Mostafa Kamal, Kazi Ashfak Ahmed Chowdhury, Afrina Jahan, Md. Shakhawat Hossain, Arafatul Mamur, Mahmudul Hasan, Javed Hossain

Abstract:
Various forms of cancer are rising all over the world, requiring newer therapy. The quest of anticancer drugs both from natural and synthetic sources is the demand of time. The present study was to investigate the cytotoxicity & thrombolytic activity of methanolic extracts Macaranga denticulata bark. An in vitro thrombolytic model was used to evaluate the clot lysis effect of different extracts of M. denticulata along with Streptokinase as a positive control and distilled water as a negative control. Plant was evaluated for cytotoxicity by brine shrimp lethality bioassay comparing with standard cytotoxic drug vincristine sulphate. The cytotoxic activity of methanolic extracts of M. denticulata bark was evaluated by Brine shrimp lethality bioassay. The brine shrimp lethality bioassay result was (LC50=57.25 µg/ml) compared with standard vincristine sulphate (LC50=0.512 µg/ml). It has significant thrombolytic activity (31.59%) compared to standard streptokinase (70%).