Vol. 4, Issue 5 (2015)

Author(s):
Priyanka Patel, Kajal Ahir, Vandana Patel, Lata Manani, Chirag Patel

Abstract:
Studies of drug-excipient compatibility represent an important phase in the preformulation stage of the development of all dosage forms. The potential physical and chemical interactions between drugs and excipients can affect the chemical, physical, therapeutical properties and stability of the dosage form. The present review contains a basic mode of drug degradation, mechanism of drug- excipient interaction like physical, chemical and biopharmaceutical. Different Thermal and Non-thermal method of analysis, Tools and software for incompatibility is also discussed. Once the type of interaction is determined we can take further steps to improve the stability of drug and dosage form. From review, we conclude that consequent use of thermal and non-thermal method provide data for drug- excipient interaction which can further help in selection of excipient for the development of stable dosage form.