Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

NAAS Rating: 5.03, Impact Factor: RJIF 5.98 | Free Publication Certificate
updates
NAAS Rating: 5.03 new
Vol. 4, Issue 4 (2015)

A comparative experimental study of antinociceptive activity of fluoxetine with pentazocine in rodent models

Author(s):
Manjunatha C. H, Jagadishchandra S. Ratnakar
Abstract:
Introduction: Chronic pain affects millions of people, commonly coexisting with depression and anxiety. Antidepressants like fluoxetine have been shown to have analgesic activity with favourable safety profile and hence might be better suited in the management of chronic pain.
Objectives: To evaluate the analgesic activity of fluoxetine and to compare the analgesic effect of fluoxetine with pentazocine.
Materials and Methods: Adult albino rats weighing 150-200 grams were used in this study. Screening method used was Eddy’s hot plate method in rats. Rats were divided into three groups of 5 animals and drugs administered as follows:
Group-1: Distilled water (control)
Group-2: Fluoxetine
Group-3: Pentazocine
All drugs were administered 30 minutes before the onset of pain stimulus.
Statistical analysis was done by using one way-Analysis of variance (one way ANOVA) followed by Tukey-Kramer test.
Results: Fluoxetine showed significant analgesic activity in hotplate method, but it was less significant than that of pentazocine.
Pages: 43-46  |  639 Views  5 Downloads
How to cite this article:
Manjunatha C. H, Jagadishchandra S. Ratnakar. A comparative experimental study of antinociceptive activity of fluoxetine with pentazocine in rodent models. 2015; 4(4): 43-46.
Journals List Click Here Research Journals Research Journals
Call for book chapter