Vol. 4, Issue 2 (2015)

Author(s):
Т. О. Pertseva, L. І. Konopkina, B. О. Basina

Abstract:
Chronic inflammation and airway remodeling are characteristics of chronic obstructive pulmonary disease (COPD). Abnormalities in hyaluronic acid, a component of the extracellular matrix, may be involved in the pathogenesis of COPD. But there are no researchers about its role like a marker of effectiveness of anti-inflammatory therapy (AIT) at patients with COPD.
The study is devoted to the diagnostic value of HA at patients with COPD, the role of the HA as a marker of the effectiveness of AIT at patients with COPD.
It was determined that the level of HA at patients with COPD before AIT was significantly higher than it at patients of the control group. But in 3 months after correction of treatment the level of HA decreased significantly at all patients comparing to previous visit, which corresponded to the level of the control group.
It means that the significant decreasing of HA level at patients with COPD may be a marker of the effectiveness of AIT.