Vol. 4, Issue 2 (2015)
Dynamics of the secretory immunoglobulin a concentration in the oral fluid of the patients with generalized periodontitis
G.D. Semeniuk, G.М. Melnychuk
The article shows the data of the completed clinical randomized, controlled, double-blind, parallel, longitudinal research of 96 somatic healthy people, aged from 18 to 35 years, including 68 patients with generalized periodontitis, who formed the main group (group А) and the comparison group (group C) and 28 persons without generalized periodontitis (control group N). We investigated the effect of the combined treatment on changes in the concentration of the secretory immunoglobulin A in the oral fluid. The quantification of SIgA in the oral fluid was conducted by the method of solidphase immunosorbent analysis. In the combined treatment of the patients of the group A except the basic initial periodontal therapy (removal of soft and hard dental plaque, detoxification and polish of roots, closed curettage) the additional drug therapy was applied: for the general treatment – synbiotic and vitamin and mineral complex, and for the local treatment - antibacterial gel, and also antiseptic preparation. The patients from the group C were treated similarly, excluding synbiotic. The Wilcoxon signed rank test (T - test) was used to assess the statistical significance of indicators difference in groups in different periods of observation for dependent samples, and to compare independent samples (groups N, A, C) – the Mann-Whitney test (U- test) was used. It was found that in the patients with chronic GP of I degree concentration of SIgA in oral fluid is reduced, or is within healthy parameters in comparison with healthy people. Under the influence of the combined treatment in patients of both groups (regardless of synbiotic) significantly increased the concentration of SIgA in the oral fluid immediately after the treatment. In the later periods of observation there was found the steady increase of SIgA level in group a (treated using synbiotic) and decrease in group C (treated without using synbiotic).
How to cite this article:
G.D. Semeniuk, G.М. Melnychuk. . The Pharma Innovation Journal. 2015; 4(2): 09-12.