Vol. 4, Issue 1 (2015)
Chemical composition, antimicrobial activities and TLC profile of different bark extracts of Cinnamomum zeylanicum
Dhia E. Elhag, Zuheir Osman, Hind Omer, Saad M. H. Ayoub, Mona. S. Mohammed, Wadah. J. Ahmed
The bark of cinnamon (Cinnamomum zeylanicum) is commonly used as spice and has also been widely employed in the treatment and prevention of diseases. The aim of the present study is to assess the antimicrobial activity of the 96% ethanolic, petroleum ether, chloroform and methanolic extracts against four standard bacterial species, two Gram-negative bacteria, (Escherichia coli and Pseudomonas aeurginosa), two Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and two standard fungal species (Candida albicans, Aspergillus niger). This study also aimed to investigate the chemical composition of the active extract and to determine the thin layer chromatography profile of different bark extracts of the plant. The results showed that all extracts exhibit significant antimicrobial activity against the tested organisms and the petroleum ether (PE) extract showed the strongest activity and was subjected to GC-MS analysis. The petroleum ether extract was composed of 99% (E) - Cinnamaldehyde which was isolated by preparative TLC. The antimicrobial activity of C.zeylanicum most probably due to the presence of (E) – cinnamaldehyde, a known antimicrobial natural product.
How to cite this article:
Dhia E. Elhag, Zuheir Osman, Hind Omer, Saad M. H. Ayoub, Mona. S. Mohammed, Wadah. J. Ahmed. . The Pharma Innovation Journal. 2015; 4(1): 33-36.