Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

NAAS Rating: 5.03, Impact Factor: RJIF 5.98 | Free Publication Certificate
updates
NAAS Rating: 5.03 new
Vol. 4, Issue 1 (2015)

Formulation and evaluation of Orodispersible tablets of candesartan

Author(s):
B.Venkateswara Reddy, K. Navaneetha
Abstract:
Candesartan cilexetil is prodrug of candesartan. It is a non-peptide angiotensin ? type-? (AT?) receptor antagonist which is used in the treatment of hypertension and congestive heart failure. It was formulated as an orodispersible tablet as there is a need to develop a formulation for this drug which overcomes problem such as difficulty in swallowing, inconvenience in administration while traveling and better compliance. Candesartan Cilexetil orodispersible tablets were prepared by coprocessed super disintegrants like Indion 204, Tulsion 339 and Primogel. Co-processing is based on the novel concept of two or more excipients interacting at the sub particle level, the objective of which is to provide a synergy of functionality improvement. A total of 12 formulations were prepared and evaluated for various pre and post compression parameters like angle of repose, bulk density, tapped density, carr’s index, hausner’s ratio, weight variation, hardness, friability, thickness, wetting time, water absorption ratio, drug content, in vitro disintegration time, in vitro drug release. The in vitro disintegration time of the optimized formulation (F9) of Candesartan was found to be 10 sec. Release rate of drug was 99.3% within 8 minutes. Thus the formulation (F9) containing Indion 204 and Tulsion 339 in 1:1 ratio were found to increase patient compliance.
Pages: 25-32  |  639 Views  15 Downloads
How to cite this article:
B.Venkateswara Reddy, K. Navaneetha. Formulation and evaluation of Orodispersible tablets of candesartan. 2015; 4(1): 25-32.
Journals List Click Here Research Journals Research Journals
Call for book chapter