Vol. 3, Issue 10 (2014)
Reviewing biomedical role of Plasma Gelsolin
Neeraj Khatri, Ashish and Veena Garg
Gelsolin is circulating in human plasma in extremely high concentrations that is exhausted by intermediaries of inflammation and largely produced by skeletal muscles. Gelsolin is a Ca2+ dependant actin-binding and an actin-depolymerizing protein. Owing to capability of gelsolin to swiftly severe F-actin, plasma gelsolin has become a very important injury healing protein in various pathological conditions. Decreased levels of the plasma gelsolin have been reported in human diseases as well as in animal models of diseases. Therefore, pGSN deficiency appears to be a powerful biomarker and a potential therapeutic target in diseases. Here, we review the biomedical functions of gelsolin and impact of gelsolin levels in different disease conditions.
How to cite this article:
Neeraj Khatri, Ashish and Veena Garg. . The Pharma Innovation Journal. 2014; 3(10): 16-20.