Vol. 2, Issue 8 (2013)

Author(s):
Т.О. Pertseva, L.І. Konopkina, B.О. Basina

Abstract:
Systemic inflammation is one of the links of pathogenesis of chronic obstructive pulmonary disease (COPD). However, the role of numerous molecular markers in various categories of patients, in phases of pathological process, depending on the presence and degree of microbial load, etc. is being currently defined and specified. It is determined that a certain part of patients with COPD (regardless of the stage), even with stable course of the diseases, may reveal increased levels of systemic inflammation markers, particularly levels of CRP and Fibrinogen, which reflect the processes of activation of chronic systemic inflammation in these very patients. The most frequent and the most marked chronic systemic inflammation is found in patients with severe course of COPD, which requires identification of such category of patients in order to minimize the risk of systemic effects formation in these patients. Sometimes, increase in the CRP and/or Fibrinogen levels in the blood plasma of patients with COPD may witness to insufficient glucocorticosteroid medication and require therapy adjustment.