Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

NAAS Rating: 5.03, Impact Factor: RJIF 5.98 | Free Publication Certificate
updates
NAAS Rating: 5.03 new
Vol. 2, Issue 7 (2013)

Assessment of Phytochemical, Analgesic and Antioxidant Profile of Melia azedarach L. [Leaves] (Family-Meliaceae)

Author(s):
MD. Shafayat Hossain, Abu Saed, Utpal Kumar Karmakar, MD. Anwar Hossain
Abstract:
This project is designed to evaluate the potential analgesic and antioxidant activity of Melia azedarach L. to judge the traditional uses of this medicinal plant. The ethanolic extract of the dried leaves of Melia azedarach L. (Family: Meliaceae) was assessed for its possible analgesic and antioxidant activity. Photochemical screening of the ethanolic extract revealed the presence of alkaloids, glycosides, tannins, Saponins and Flavonoids. In acetic acid induced writhing in mice, the ethanolic extract (250 and 500 mg/kg) exhibit significant (P<0.001) inhibition of writhing reflex 45.45% and 67.05% respectively compared to standard Diclofenac Sodium 76.14% (P<0.001) at a dose 25mg/kg body weight. The ethanolic extract showed antioxidant activity. In qualitative antioxidant assay using 1, 1-diphenyl-2-picryl hydrazyl the extract showed free radical scavenging properties. In the quantitative assay, extract displayed free radical scavenging activity in the assay (IC50~95µg/mL) which is comparable to that of ascorbic acid (IC50 ~15µg/mL), a well-known standard antioxidant.
Pages: 64-69  |  619 Views  19 Downloads
How to cite this article:
MD. Shafayat Hossain, Abu Saed, Utpal Kumar Karmakar, MD. Anwar Hossain. Assessment of Phytochemical, Analgesic and Antioxidant Profile of Melia azedarach L. [Leaves] (Family-Meliaceae). The Pharma Innovation Journal. 2013; 2(7): 64-69.
Journals List Click Here Research Journals Research Journals
Call for book chapter