Vol. 2, Issue 5 (2013)
Features of the Hereditary Apparatus of Long Livers Living in Different Carpathian Ecological Regions.
The analysis of the frequency and spectrum of chromosomal aberrations, acrocentric chromosomes’ associations, micronuclei of 264 long livers and 218 persons (control group), depending on environmental conditions has been done. Analysis of the frequency of micronuclei showed the increasing of instability of all patients’ hereditary apparatus, correlating with the intensity of pollution. The average group frequency of chromosomal aberrations of long livers, depended on environmental conditions was found. Therefore, for people living in positive ecological regions, the figure was (2,85 ± 0,25), in the zone of satisfactory environmental pollution - (2,98 ± 0,24) and in the regions of bad environmental conditions- (3,05 ± 0,15 %). That was respectively 1.5, 1.7 and 1.8 (p <0.05) fold reduction (control group). At the same time, individual variability of chromosomal aberrations’ frequency among long livers ranged from 0.2 to 5%. Studying the rate of acrocentric chromosomes’ associations, the significant age and sex changes of all examined long livers were not found. The results of frequency of acrocentric chromosomes’ associations correlated with indicators of the frequency of chromosomal aberrations (ranged from 0.73 to 0.9), having confirmed the negative impact of environmental conditions on the immunogenetic status and human adaptive capacity.