Vol. 2, Issue 5 (2013)
Role of Aldosterone, Mitogenic Growth Factors, Apoptosis Inducers and Pulmonary Arterial Hypertension in the Formation and Progression of Chronic Pulmonary Heart Disease
We have investigated the role of mineralocorticoid aldosterone, mitogenic growth factors – fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), apoptosis inducer Fas-Ligand (FasL) and pulmonary arterial hypertension (PAH) in the formation and progression of chronic pulmonary heart disease (CPHD). I was found that increased levels of aldosterone, mitogenic growth factors bFGF and VEGF, apoptosis inducer FasL and PAH were observed in cases of decompensated CPHD with development and progression of chronic heart failure.