Vol. 1, Issue 9 (2012)

Author(s):
R.Margret chandira, Debjit Bhowmik, Rahul Yadav, B.Jayakar, K. P. Sampath Kumar

Abstract:
The purpose of the study is to investigate the effect of roller compaction (RC) parameter (auger speed) on the properties of flakes, granules and tablets. This study is carried out in six formulation preparing by changing auger speed(6-7, 10-11, 14-15, 18-19, 23-24, 27-28 rpm) of roller compactor resulting in flakes of different hardness were prepared, and its impact on the flow properties(bulk density, tapped density) of the granules and finally its effect on the properties of tablet such as hardness, thickness, friability. For this study ibuprofen is the model drug selected and the tablets formed by changing the auger speed is of ibuprofen. In this study the tablet’s in vitro drug release were also performed and compare with the marketed ibuprofen tablet.