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Vol. 1, Issue 7 (2012)

Evaluation and Characterization of Different Polymers Based Drug Theophylline In Pulsatile Drug Delivery System

Author(s):
Grover Chandani*, Bhatt Ganesh, Kothiyal Preeti
Abstract:
Novel Oral Drug Delivery technologies have emerged and expanded into different drug delivery system with different drug release mechanisms. Pulsatile drug delivery system (PDDS) is  the most interesting  time - and site-specific system as per the patho-physiological need of the disease.. Pulsatile drug release  profile is  characterized by time period of  no release  (lag time) followed by a rapid  and complete drug release. The objective of the present study was to develop an oral pulsatile drug delivery system and evaluating and doing comparative characterization of different polymers used in the formulation of pulsatile drug delivery system. The core tablet was formulated using Drug- Theophylline ,polymers-HPMC K4M, XANTHAN GUM and combination of HPMC K4M + XANTHAN GUM. Further Excipients employed were Lactose, Microcrystalline Cellulose, Starch, Sodium Carbonate, Citric Acid, Cross Carmellose Na ,Magnesium and Sodium Stereate. The method adopted was Direct Compression Method. Eudragit L-100 in acetone (6%w/v) was enteric coated over the Press Coated tablet to formulate Pulsatile Tablet. From the evalution and results, we conclude that the drug release from the pulsatile tablet formulated with  polymer HPMC K4M+Xanthan gum shows more efficient drug release than pulsatile tablet formulated with only polymer HPMC K4M or tablet formulated with only polymer Xanthan Gum. The reason behind this is that Xanthan Gum is a natural polymer and Xanthan Gum exaggerate the action of HPMC K4M i.e. it has a tendency to imbibe water as well and thereby get swelled to that extent that it bards the drug release for a definite time. Hence when after the function of gum gets terminated, the drug is released to the desirable organ to show its therapeutic action and therefore Gums shows positive effect when used with PLOYMER LIKE HPMC K4M.
Pages: 105-112  |  572 Views  2 Downloads
How to cite this article:
Grover Chandani*, Bhatt Ganesh, Kothiyal Preeti. Evaluation and Characterization of Different Polymers Based Drug Theophylline In Pulsatile Drug Delivery System. 2012; 1(7): 105-112.
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