Vol. 1, Issue 5 (2012)
Development and In Vitro Evaluation of Buccoadhesive Tablets of Losartan Potassium
The buccoadhesive tablets of Losartan Potassium were developed to prolong the drug release and to improve the bioavailability of the drug by avoidance of the hepatic first pass metabolism during the treatment of chronic hypertension. The formulations were tested for weight variation, hardness, friability, content uniformity, swelling index, bio- adhesive time and the drug release rate. The Carbopol 934P was used as the bio-adhesive polymer, HPMC K4M and HPMC K15 M was added as a matrix former. The ethyl cellulose was used as the backing layer. The optimised formulation containing Carbopol 934P and HPMC K4M (in the ratio of 1:1) showed the surface pH value in the range of 6 to 7 and 94.49% of drug was released in 10hours and showed the best bio- adhesive time up to 11 hours.
How to cite this article:
G. Praveen. Development and In Vitro Evaluation of Buccoadhesive Tablets of Losartan Potassium. 2012; 1(5): 63-70.